https://www.sciencedirect.com/science/article/pii/B9780123864543007764, https://www.sciencedirect.com/science/article/pii/B0123694000008115, https://www.sciencedirect.com/science/article/pii/S0091743584710462, https://pubmed.ncbi.nlm.nih.gov/19476015/, https://pubmed.ncbi.nlm.nih.gov/16784007/, https://www.sciencedirect.com/science/article/pii/S1879729614001665, https://www.rhinologyjournal.com/Abstract.php?id=719, How to Sleep While Taking Sertraline (Zoloft) Doctors 6 Tips, 9 Oak Bedroom Furniture Ideas (Pro Designers Picks), How to Decorate a Bedroom with Blue Carpet, 20+ Trending Bedroom Design Styles for 2022, Emma ComfortAdapt Hybrid Mattress Review (July 2022 Discounts), Puffy Lux Hybrid Mattress Review (June Discounts), Does Benadryl Make You Sleepy? You may report side effects to the FDA at 1-800-FDA-1088. Moreover, when treatment is discontinued, there is a rebound increase in the dilation of the vessels and recurrence of congestion [11]. You can buy a large container to hold water and keep it with you always to make sure you stay hydrated. Sudafed is removed from the body through various mechanisms. Intense exercise can cause muscle injury that causes your body to release waste products in excess. Eur Ann Otorhinolaryngol Head Neck Dis [Internet]. not methemphetamine. Treatment will depend on your medical history, symptoms, and the results of any laboratory studies and other diagnostic tests. When will it stop showing up in a urine test? The nicotine present in tobacco has a similar stimulatory effect on the body to Sudafed. You can learn more about how we ensure our content is accurate and current by reading our. Biochem Pharmacol [Internet]. The effects of a hot drink on nasal airflow and symptoms of common cold and flu. Can You Take A Z-Pak If You Have A Penicillin Allergy? Some sexually transmitted diseases can cause urination disorders, including the change in color, abnormal urine odor or cloudy look. Some diseases require immediate attention and can develop complications if not treated on early stages. It is based on pseudoephedrine hydrochloride (the active ingredients of Sudafed 12 hour) and Sudafed 12 hour (the brand name). Abstract and Figures. The half-life of pseudoephedrine is between 5 and 8 hours, though the more acidic the urine, the lower the half-life. Mild dehydration can be easily treated with water, while serious cases can represent health danger and require urgent medical assistance. Along with its needed effects, pseudoephedrine (the active ingredient contained in Sudafed Congestion) may cause some unwanted effects. It's normal to have low levels of protein in your urine as part of this. Our phase IV clinical studies alone cannot establish cause-effect relationship. Nasal irrigation using bulb syringes, nasal spray bottles, and specialized devices can be done to open the clogged sinuses. pedclerk.bsd.uchicago.edu/page/abnormal-urine-colors, mayoclinic.org/diseases-conditions/dehydration/basics/symptoms/con-20030056, mayoclinic.org/diseases-conditions/urine-color/basics/symptoms/con-20032831, merckmanuals.com/home/kidney-and-urinary-tract-disorders/symptoms-of-kidney-and-urinary-tract-disorders/urination,-excessive-or-frequent, urologyhealth.org/careblog/the-meaning-behind-the-color-of-urine, labtestsonline.org/understanding/analytes/urinalysis/tab/glance, Urinary Tract Infections: A New Antibiotic May Be on the Way to Treat UTIs, New Home Kidney Test Uses Smartphone to Monitor Kidney Health, side effects of blood-thinning medications. Review/update the When liver is not working properly, bilirubin is not removed from the body. Maybe youll need a little longer if you took it at very high doses. Drug information provided by: IBM Micromedex. Available from: https://pubmed.ncbi.nlm.nih.gov/19476015/, 10. Elderberry (Sambucus nigra) is the dark purple berry from the European elder tree. Drinking a hot drink can also provide relief from the common cold and congestion [13]. Amphetamines can be detected in the blood for four to six hours, in the saliva for 24 to 48 hours, in urine for up to four days and in the hair for up to 90 days. Try to remember if you have eaten something that is normally causing dark urine, particularly beets, blackberries, asparagus, or have taken some drugs. Although not all of these side effects may occur, if they do occur they may need medical attention. In fact, it means the opposite: it explains that you're absorbing caffeine from food sources like beans and tea instead of from beverages like soda pop. Some side effects may be more likely in older adults and in people who have severe kidney disease. In a study by Cody, et al., where subjects ingested Adderall 20 mg daily for five days, urine drug concentrations declined following drug discontinuation to below the Aegis threshold of 250 ng/mL after 27 to 45 hours, depending on the patient. Porphyria is a genetic disease. 2010 Mar 15;79(6):8019. J Investig Allergol Clin Immunol [Internet]. If you see any change in urine color, dont panic and check whether it is due to your food habit or medication. It is created by eHealthMe based on reports of 3,570 people who have side effects while taking Sudafed 12 hour from the FDA, and is updated regularly. O 0. Dark urine is deeper in color than urine that is usually straw to yellow in color. Guaifenesin is an expectorant that helps thin and loosens mucus in the lungs, making it easier to cough up the mucus. If your urinalysis reveals unusual results, your doctor may order more targeted tests. However as long as he is not a professional sportsman then taking this should not cause a problem with drug testing. Urine drug screens are a very useful tool for health care professionals, but they can sometimes be a bit problematic as we sometimes get false positives. Dark urine due to food, drink, or medications is not usually a cause for concern. Drinking a lot of water can help flush Sudafed out of the body faster. Phenylephrine has a half-life of about 2.5-3 hours, which means that your body eliminates half of the dose within about 3 hours. So if a person smokes and is using Sudafed, the chances of getting a night of good quality sleep will be decreased markedly. Sudafed 12 Hour Pseudoephedrine Pseudoephedrine Hydrochloride Sudafed 24 Hour Suphedrine Show more brands Additional Terms for Urine Colour Abnormal Dark Coloured Urine Dark Urine Change In The Color Of My Urine Discolored Urine Discolored Urine/fecal Matter Show more This report is for all products sharing this active ingredient. Urobilin is a waste product, resulting from hemoglobin breakdown, necessary for blood cells renewal. The latest is caused by excessive yellow pigment, or bilirubin, produced during the dead blood cells breakdown. To apply a warm compress, soak a towel in warm water, squeeze the towel to remove the water, and place it over the forehead and nose. As a result the RBCs get trapped in small vessels and cant reach to different parts of the body. However, check for additional symptoms and remember that dark yellow urine can also be caused by serious health problems, including hepatitis, jaundice, gallstones and more. All rights reserved. According to the NHS, the side effects associated with Sudafed use are headaches, dry mouth, increased blood pressure, irregular heartbeat, and sleep disturbance due to the pseudoephedrine content. Sudafed products, such as Mucinex DM contains two key ingredients: dextromethorphan and guaifenesin. Even a small drop of blood can change the urine color to dark yellow or brown. The results can be urine that is either pink or cola-colored. This system, when activated, prepares the person for stressful situations and flushes the body with hormones. Common tests can detect amphetamines for up to four days. If you are in need of help because you've taken pseudos in the past week, you're going to need Quick Fix. I took sudafed and now I have dark urine. However, urine color can vary depending on your choice of foods, health conditions, or medications. information is beneficial, we may combine your email and website usage information with Cerner Multum, Inc. "Australian Product Information." It is important to take sudafed, or any other medication as directed. W F Seidel 1, M Maze, W C Dement DME. I think it caused a false-positive drug test. Go to a doctor right away Serious . Brown urine can be caused by: Food. Urine naturally has some yellow pigments called urobilin or urochrome. When it is used for a prolonged period, its stimulatory effect is decreased. It destroys liver cells and stops it from functioning normally. 2019/07/05. Alcohol abuse and autoimmune system failure are the other reasons. The darker urine is, the more concentrated it tends to be. 2023 - Bedroom Style Reviews - All Rights Reserved. The combination of nicotine and pseudoephedrine can have disastrous effects on your sleep. It is commonly transmitted by hepatitis A virus contaminated food or drink. The sooner it is diagnosed, the more chances you will have to survive. It might. Prev Med (Baltim) [Internet]. Get emergency help immediately if any of the following symptoms of overdose occur: Check with your doctor as soon as possible if any of the following side effects occur: Some side effects may occur that usually do not need medical attention. Any change in the color of the urine not due to eating certain foods or taking certain medications should be reported to your doctor. Also, do not mix alcohol with. How long does phenylephrine stay in your system? B Bertrand 1, J Jamart, J L Marchal CA. One common over-the-counter drug that can cause a false positive urine drug test is the nasal decongestant phenylephrine (as well as the similar nasal decongestant pseudoephedrine) due to its structural similarity to amphetamines. You may report them to the FDA. Rhinology [Internet]. False-positives can occur because they typically arent looking for a specific drug in your urine. Ask his testing organisation to run a MS/GS on the sample to avoid false positive for other drugs. While it is true that Pseudoephedrine may be detected as amphetamines (speed), the likely-hood is largely dependent upon the quality of the drug test. The Relation Between Cigarette Smoking and Sleep Disturbance. This site complies with the HONcode standard for trustworthy health information: verify here. desmopressin acetate. Several different reports and studies exist that establish a link between using it and registering a false positive for amphetamines / methamphetamine (including this one from the Mayo Clinic). Urinary tract infections caused by a certain type of bacteria can cause green urine. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Applies to pseudoephedrine: compounding powder, oral capsule, oral liquid, oral suspension extended release, oral tablet, oral tablet chewable, oral tablet extended release. 9 Ways to Sleep Better When Taking Sudafed, 4: Take Sudafed in Combination with Antihistamine, 9: Take Standard Precautions While Using Sudafed. If you feel you received a false positive test result, be sure to talk to your doctor and tester about allthe drugs and supplements you take. Some disease and health conditions also changes the urine color into a darker one. The urine will return to its normal color once a person stops consuming whatever is causing the change. Pseudoephedrine can be illegally used to manufacture methamphetamine, which has become a national epidemic. One immediate-release tablet of pseudoephedrine lasts anywhere from three to eight hours. They are confusion, abdominal swelling, swelling in the legs, gynecomastia, breast atrophy in female, impotence etc. Chronic dark-colored urine can be related to serious liver conditions, including Hepatitis and Jaundice. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Hematuria is the medical term for blood in urine. This content does not have an Arabic version. Do not use untreated tap water, as it is not safe for your health. Their size can range from size of a grain to the size of an apricot. Let your physician know about your other medications and any OTC drugs or herbal supplements. It is usually taken as needed, but prolonged use should be avoided. A study done in the USA revealed that the addition of Desloratidine to the pseudoephedrine was associated with a lower incidence of insomnia when compared to those who received Sudafed alone [9]. And contact your doctor immediately is you see blood in your urine. The use of the eHealthMe site and its content is at your own risk. Gas chromatography, mass spectrometry, or d/l isomer tests all can distinguish between a false positive and true positive test since they detect actual compounds in a given sample, and do not rely on antibody reactions. Gorodetsky R. Pseudoephedrine. Sudafed passes into breast milk and may harm a nursing baby. Clear urine may also be used to describe whats medically called colorless, Urine should typically be clear and not murky, though the color can vary. One immediate-release tablet of pseudoephedrine lasts anywhere from three to eight hours. Hepatitis B is another option. Blood urine is reported only by a few people who take Sudafed 12 Hour. Tamiflu belongs to. Causes of Chlamydia infections unprotected sex, newborn baby can get this infection from infected mother during the borth process. If you notice any other effects, check with your healthcare professional. All rights reserved. Mitchell HA, Weinshenker D. Good night and good luck: norepinephrine in sleep pharmacology. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. When we breathe in this moist air, it improves the patency of our airways. Very dark honey- or brown-colored urine could be a sign that you're dehydrated and need to get more fluids right away. Taking Sudafed before a urine drug test might lead to a false positive methamphetamine screening result. Dan is a qualified NVQ Level 2 Fitness Instructor with 6 years experience helping clients improve their health through diet, exercise, and proper sleep hygiene. I have it on my medical HelloPharmacist This method is also approved by the Food and Drug Administration (FDA). Beans, beets, blackberries, carotene, B vitamins, some food colorings can make it darker. If your dark urine is due to insufficient fluid intake, you should start drinking more water. Four good reasons to indulge in cryptocurrency! Learn more. pai when lying on your back and the pain increases when sitting up etc. Many over-the-counter cold medications are or include antihistamines, such as: Allegra Benadryl Claritin Zyrtec Dramamine Bonine NyQuil Why do some medications dehydrate you? Pseudoephedrine may be better known as the decongestant agent in products like Sudafed, but its also an amphetamine class chemical. It is created by eHealthMe based on reports of 3,570 people who have side effects while taking Sudafed 12 hour from the FDA, and is updated regularly. Combining an antihistamine with pseudoephedrine can help with insomnia and difficulty sleeping. Sudafed can keep you awake and cause insomnia because it contains pseudoephedrine that has a stimulatory effect on the body increasing norepinephrine levels, stimulating the nervous system, and increasing blood pressure. Remember, only a doctor can provide you with comprehensive diagnosis. The fix: Really, coffee-smelling pee is NBD, but the fact that coffee is . Sudafed is removed from the body through various mechanisms. Abnormal color can be accompanied with unpleasant odor or cloudy look. Medicines. The first signs of an acetaminophen overdose include loss of appetite, nausea, vomiting, stomach pain, sweating, and confusion or weakness. If we combine this information with your protected A number of factors, from diet to drugs to disease, can cause changes in, Clear urine describes urine that doesnt have any sediment or cloudiness. If you experience these symptoms, do not hesitate to visit a doctor. These red blood cells can originate from any part of the urinary tract, including the kidneys, bladder, prostate (if male), and urethra.Hematuria can be detected both by your own eyes and with a microscope. It is definitely an everyday item that can cause you to fail a drug test. Dark urine can also be caused by other less common, yet dangerous conditions. Due to this, sometimes an unrelated drug may cause a reaction, and thus, a false-positive result. We do not provide medical advice, treatment or diagnosis. Urinary tract infections caused by a certain type of bacteria can cause green urine. The ureters are tubes that connect the kidneys to the bladder. Being an over-the-counter substance, albeit a tightly controlled one, pseudoephedrine is not commonly targeted in drug tests, not even extended ones. Create a stylish bedroom and get better sleep with our product reviews, guides, and decor tips written by industry-leading experts. If you're stuffed up and looking for relief, Sudafed is one medication that could help. If your symptoms are not improv Can taking sudafed and claritin (loratadine) cause dehydration after two weeks of taking? I am currently taking 150 mg of Zoloft daily and w Can you take white mulberry with Eliquis? These are the other symptoms confirming the presence of an issue. byproducts from coffee after it gets broken down in your body). Staff. Kidneys perform essential functions in your body, filtering waste and producing hormones. Some people have urine that appears almost syrup-like. Related: click here to see the top mattresses we have reviewed to help you sleep better. Main image: Pseudoephedrine by Hailshadow (Getty Images Signature) used with permission under the terms of Canvas One Design Use License Agreement. Chemical tests include information about bilirubin, blood. include protected health information. 4. When you're dehydrated, your urine becomes concentrated and darker in color. Cerner Multum, Inc. "UK Summary of Product Characteristics." Amphetamine can be detected in a urine test for two to five days since the last dose. Dr. Paul Grin answered. People with chronic kidney disease can now monitor their kidney health at home, using a test kit and a smartphone. In more severe state the following symptoms can be seen. When you take in fluid or food, it passes from your digestive system, into your circulatory system, and into your kidneys where it is filtered. elevated blood pressure, tachycardia, or arrhythmias), CNS stimulation (e.g. I researched it Related Medical Questions My daughter is 1yr and 8mths she can't keep no liquids down. If you take detox cleanses or pills, it's going to be too late and it won't work. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. The vyvanse (lis. Consult your doctor before taking Sudafed . Its always a good idea to provide the lab or your physician with a list of medications that you are presently taking, as well as any over-the-counter herbals or supplements. Later symptoms may include pain in your upper stomach,. As we all may know, there is an opioid crisis in the United States. Sometimes its difficult to tell the difference between dark urine due to dehydration or due to other causes. Currently 350 million people all over the world is suffering from this chronic disese. Dark yellow urine is typically caused by dehydration. Add custom text here or remove it. Pseudoephedrine stimulates the beta receptors, resulting in tachycardia and increased blood pressure. Irritation and sleep disturbance will also improve. unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine. They are hepatitis A,B,C,D & E. Chronic hepatitis C infection and alcohol abuse are the commonest cause of liver cirrhosis. In other cases dark urine can represent a symptom of certain health issues, including STDs, internal bleeding and other disorders that require professional medical treatment. It does not represent any danger for your health and goes away after some time. Dr. Thomas Josa answered. All rights reserved. Moist air provides a soothing effect to the engorged and irritated nasal mucosa. Up next: 21 ways to sleep with back pain and sciatica. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Senna and cascara, metronidazole and nitrofurantoin, quinine and chloroquine, methocarbamol are the examples. Laccourreye O, Werner A, Giroud J-P, Couloigner V, Bonfils P, Bondon-Guitton E. Benefits, limits and danger of ephedrine and pseudoephedrine as nasal decongestants. Pseudoephedrine, the active ingredient in Sudafed, is known to worsen symptoms of a condition known as benign prostatic hyperplasia because the medicine causes tightening of the muscles in the . Dark brown or cola-colored urine. Hepatitis can affect the livers ability to perform critical body functions, such as metabolism, toxin filtering, bile production, storage of minerals and other tasks. I have no other symptoms. You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood. Pseudoephedrine activates the sympathetic system and gives the body a sense of energy. Check whether Blood urine is associated with a drug or a condition, Blood urine and drugs with ingredients of pseudoephedrine hydrochloride, Blood urine in Pfizer BioNTech Covid Vaccine, Blood urine in Johnson and Johnson Covid Vaccine, Klonopin and Diabetes Mellitus Inadequate Control, Lidocaine and Doxycycline drug interaction, Vaginal Yeast Infection: 1 person, 100.00%, Oedema Peripheral (superficial swelling): 1 person, 100.00%, Cellulitis (infection under the skin): 1 person, 100.00%, Appetite - Increased (increased appetite is when you want to eat much more often or in larger quantities than your body requires): 1 person, 100.00%, Osteoporosis (bones weak and more likely to break): 1 person, 100.00%. When the body does not receive enough water, it increases the concentration of urobilin in the urine. Video chat with a U.S. board-certified doctor 24/7 in less than one minute for common issues such as: colds and coughs, stomach symptoms, bladder infections, rashes, and more. When a person does not receive enough liquid, there is a higher concentration of waste products in urine, including dead blood cells, toxins, proteins and other products that need to be removed from the body. Conditions associated with dark urine include: Excess or overly strenuous exercise can also contribute to dark urine. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Lewis ED, Meydani SN, Wu D. Regulatory role of vitamin E in the immune system and inflammation. Urine drug screens generally dont look for the drug directly, they screen for known metabolites based on reactions with antibodies. The medication is available in the following forms: oral capsule and oral liquid suspension. Pseudoephedrine acts through multiple mechanisms that can keep you awake as described below [4]: Pseudoephedrine displaces norepinephrine from its storage site, resulting in increased levels of norepinephrine in the body that cause sleep disturbance. All rights reserved. However, dark red urine could mean that there is blood in your urine . The simple answer is that your body is likely dehydrated and needs more fluids. Check with your doctor as soon as possible if any of the following side effects occur while taking pseudoephedrine: Some side effects of pseudoephedrine may occur that usually do not need medical attention. What is the dose for a 128lb person for sudafed. Labetalol: Labetalol (Trandate) is both an alpha- and beta-blocker drug used for blood pressure control. Some reports may have incomplete information. A lot of these standardized drug tests have a fairly high false-positive response, where it seems as though anything is likely to show up no matter what you took. We avoid using tertiary references. The Amazon logo are trademarks of Amazon.com, Inc, or its affiliates. WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health. . Is White Mulberry Safe To Take With Eliquis? Additional Information. Put distilled or boiled and cooled tap water in the irrigation device. Due to this, sometimes an unrelated drug may cause a reaction, and thus, a false-positive result. Sudafed should be used for less than 10 days to avoid prolonged side effects. And this needs urgent medical attention. That smelly urine odor is due to coffee metabolites (a.k.a. The study uses data from the FDA. Urination, excessive or frequent. 2009/10/13. epinephrine topical, pseudoephedrine, phenylephrine nasal, sodium chloride nasal, Afrin. Glaxo Wellcome (2001): 2. Elimination of Sudafed is increased when urinary pH is alkaline and decreased when it's acidic. R E Grubbe , W R Lumry RA. When you're dehydrated, your urine typically turns dark yellow, gold, or even brown. Conclusion. Instead, they are usually looking for a known metabolite to react with an antibody. Try these 6 ways to sleep better when taking Adderall. Certain types of foods and medications have the ability to change the color of urine. Dehydration occurs when you don't drink enough or if your body loses too much fluid from vomiting, diarrhea, heavy sweating, or too much exercise. A humidifier can be run during the day in the office and at night. 80% gallstones are made of cholesterol and 20% gallstones are made of calcium salts & bilirubin. Studies have shown that Sudafed starts producing its effects within 30 minutes of its administration, stays in the body for about 6 to 8 hours, and is then excreted through urine [7]. How long does Sudafed 24 hour stay in your system? Efficacy and safety of desloratadine/pseudoephedrine combination vs its components in seasonal allergic rhinitis. Different individuals may respond to medication in different ways. This is not a complete list of side effects and others may occur. Decreases urine output made by your kidneys. 3,570 people reported to have side effects when taking Sudafed 12 hour. Because Sudafed is a stimulant, its combined use with other stimulants should be avoided. A rare disease called familial benign hypercalcemia can cause children to have blue urine. Sudafed congestion & headache relief day & night capsules This combination pack contains two types of capsules for relieving cold and flu symptoms - we give advice on their use, warnings and side. information and will only use or disclose that information as set forth in our notice of Last updated on Sep 16, 2022. Last medically reviewed on April 19, 2019. Serious side effects of Sudafed include high blood pressure, heart attack, abnormal heartbeats, and ischemic colitis. Find out why you can test negative and still have, Officials say the antibiotic gepotidacin is performing so well in trials that it may be available sooner than expected for treatment of UTIs. Answered by Dr. Brian Staiger, PharmD wound caused by injection syringe, razor etc which is contaminated with hepatitis B virus can also transmit this disese. The meaning behind the color of urine. But in sickle cell disease the RBCs are abnormal crescent shaped which makes them sticky and rigid. A warm compress can relieve nasal congestion, flu, and blocked sinus. Although dark urine color can be caused by mere dehydration, it typically represents a bigger problem when matched with back pain. Hello, how long does phenylephrine nasal congestion stay in the urine? If the side effects are too severe, the drug should be withdrawn. Pour the water into the upper nostril. There is no other way around it. 1995; Available from: https://pubmed.ncbi.nlm.nih.gov/7562559/, 7. Rhinitis Medicamentosa is a disease in which a person experiences nasal congestion due to prolonged use of nasal decongestants [10]. The clinical effects of a single intravenous bolus dose of phenylephrine are short lived and needs to be repeated every 1015 minutes. 2019 Apr;71(4):48794. A Sanu RE. Normal urine is clear in appearance and has a straw-yellow color which comes from a pigment called urochrome. Because, like most cold remedies, the medication's main ingredient is pseudoephedrine, which is a type of synthetic amphetamine (as we covered above); avoid Sudafed for at least 48 hours before a drug test, and if you take the medication for allergies, feel free to sneeze away during your urine test. The immune system is like your internal army that fights off germs. Feel free to send him an email at Hello@HelloPharmacist.com! Used for sinus and nasal congestion, pseudoephedrine (Sudafed) can be the cause of false positive tests for amphetamine or methamphetamine. Hair tests can detect the drugs for up to 90 days. If you have these symptoms, its important to see a doctor. The opinions expressed about the independently selected products mentioned on this site are those of the publisher, not Amazon. Here are a few medications that can lead to brown urine. Ultimately, you could die from sudafed overdose. inability to micurate (requires immediate treatment), pain in the upper right quadrant of abdomen, yellow or green discharge from penis or vagina, bite of a female Anopheles mosquito which is infected by Plasmodium group of parasites, transmission from mother to baby during birth, pain immediately after taking food or drinking. These symptoms can be the evidence of a wide range of health issues, particularly in the liver and urogenital system. I experienced dark urine after the first pill but took the other two because I didn't know dark urine was listed as a serious side effect. No: Perhaps your eyes, nose and throat can feel dry but it should cause actual dehydration which can be evidenced by dark and minimal urine output.